Perrotti et al., Topical Nifedipine With Lidocaine Ointment vs. Active Control for Therapy of power Anal Fissure,” Dis Colon Rectum, 2002, 45(11):1468-1475.
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In one other facet, the present invention provides a way of treating, alleviating or preventing a dermatological or mucosal illness or dysfunction, comprising administering topically to a subject having the illness or disorder a therapeutically effective quantity of the oleaginous compositions or the oleaginous water-in-oil emulsions of the current invention.
Another class of froth adjuvants, in accordance with one or more embodiments of the present invention, contains fatty acids having 16 or extra carbons in their carbon chain, comparable to hexadecanoic acid (C16) stearic acid (C18), arachidic acid (C20), behenic acid (C22), octacosanoic acid (C28), as well as fatty acids with longer carbon chains (up to C50), or mixtures thereof.
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The method might further includes the step of adjusting the type and focus of surfactant and gelling agent to provide a foamable composition. The usage of a potent solvent in a foam composition offers an improved methodology of delivering poorly soluble therapeutic agents to a goal space.